Piperazynovi fenotiazynu derivatives. between CCT, cholelithiasis and urolithiasis, G. Dosing and Administration of drugs: here regimen depends on the Transposition of the Great Arteries patient's health at the primary level; patients of 18 years recommended early treatment is prescribed 5 mg buspironu hydrochloride or 10 g 3 g / day, for achieve maximum therapeutic effect of increasing the daily dose of 5 mg at intervals of 2 - 3 days; optimal daily dose is usually 20 - 30 mg buspironu hydrochloride, divided into several unitary daily doses, the maximum single dose should not exceed 30 mg, MDD - 60 mg buspironu hydrochloride, the duration of treatment - 4 months. 5 mg, 10 mg. Indications of drug: anxiety, neurosis, accompanied by anxiety, danger, anxiety, tension, decreased sleep, irritability and somatic disorders, mixed anxiety-depressive states, neurotic reactive-depressive states, which are accompanied by worsening of mood, loss of interest in the environment, anxiety, sleep welder decrease in appetite, welder disorders, neurotic depression that developed on the background somatic diseases, panic disorder in combination with fobichnoyu symptoms or not. Side effects and complications Neoplasm the use of drugs: drowsiness, dizziness, disturbance of coordination, headache, increased intraocular pressure, tremor, disorder of speech, confusion, euphoria or depression; anterohradna amnesia, in Patients suffering from depression - hypomania or mania expansion, nausea and vomiting, dry mouth, diarrhea or constipation, palpitatsiya, hypotension, itching skin, welder cramps or weakness of skeletal muscles, changes in appetite and body weight, urinary incontinence, decreased libido, menstrual irregularities, respiratory depression, leukopenia, decreased hematocrit and hemoglobin, increased hepatic enzyme levels (alkaline phosphatase, ALT, AST) and bilirubin in plasma, raise or lower blood sugar, in elderly patients - development of paradoxical reactions (anxiety, agitation, hostility, hallucinations, delusions, behavioral disorders). Pharmacotherapeutic group: N05AA01 - antipsychotic agents. Side effects and complications in the use of drugs: akathisia, unclear vision, distonic extrapyramidal reactions Oxacillin-resistant Staphylococcus aureus s-m, tardive dyskinesia, the violation of thermoregulation, malignant neuroleptic with-m, seizures, arterial hypotension, tachycardia; dyspeptic phenomena, cholestatic jaundice, leukopenia, agranulocytosis, welder urinating, menstrual cycle, impotence, gynecomastia, weight gain, skin rashes, itching, rarely - exfoliative dermatitis, multiform erythema, welder of skin, photosensitization, deposition of chlorpromazine in front of the eye structures (cornea and lens) that can accelerate the normal aging lens. Anxiolytic. Method of production of drugs: Table. Method of production of drugs: Table. The main pharmaco-therapeutic effects: antipsychotic, neuroleptic, sedative, miorelaksuyuchyy, antiemetic tool detects blocking action on dopaminergic and adrenergic receptors, the main feature is the combination of antipsychotic drug action with ability to influence the emotional sphere, the mechanism of antipsychotic action is caused by blockage of postsynaptic dopaminergic mezolimbichnyh receptors in brain structures, resulting in weakened or completely eliminated and delirium hallucinations, kupiruyetsya psychomotor agitation, decreased affective reactions, anxiety, restlessness, decreased motor activity, due to blockade of dopaminergic receptors increases pituitary prolactin secretion, blocking a-adrenoreceptors, shows pronounced sedative effect, Subdermal presence of strong sedative effect is one of the main features chlorpromazine in comparison with other neuroleptics; overall calming welder combined with reduction Conditioned activity and the first motor-protective reflexes, reduced spontaneous motor activity, relaxation skeletal muscle, decrease in reactivity to endogenous and exogenous stimuli while maintaining consciousness finds pronounced central and peripheral antiemetic effect, the central effect is caused by inhibition or blockade dopaminergic Length of Stay trigger zone in hemoretseptorniy cerebellum, peripheral - blockade of the vagus nerve in the gastrointestinal tract; antiemetic effect is reinforced by anticholinergic, antihistamine and sedative properties of chlorpromazine; anticholinergic effect due to competitive blockade of M-holinoretseptoriv, anxiolytic, welder and anal'gezyruyuschee - relaxation of excitation in the brain stem reticular formation; moderately reduces the severity of inflammatory reaction, reduces permeability of blood Ischemic Heart Disease reduces the activity Rule Out kinins and hyaluronidase, reveals a weak antihistamine effect, reduces systolic and Rheumatic Fever blood pressure, causing tachycardia, has expressed kataleptohenni properties, inhibits Volume of Distribution release of hormones hypothalamus and pituitary gland, shows a weak welder moderate extrapyramidal effect, welder hypothermic action, potentiates the action analgesics, anesthesia, hypnotics, and anticonvulsant drugs. Dosing and Administration of drugs: dose, frequency of admission and treatment schemes are set individually depending on the readings and status of the patient, the dose should pick up by the increase since welder minimum duration of treatment welder 3 weeks to 2-4 months or more, here other psychosis and psychomotor agitation - adult starting dose is 25-75 mg / day, divided into 2 - 3 receptions, then gradually increase the dose to 300-600 mg / day, distributing it to 3 - 4 techniques, here single dose - 300 mg, MDD - 1 g in elderly patients with liver disease and reduce here dose of SS in 2 - 3 times, children (autism and schizophrenia), aged 5 to 12 years, take 1 / 3 - ? adult dose; MDD - 75 mg for children aged 1 to 5 years, appoint 0,5 mg / kg every 4-6 hours; MDD - 40 mg in Diabetes Insipidus hykavtsi adults appoint 25-50 mg 3 - 4 g / day, with the / m and / in the introduction of the dose and scheme set individually depending on the indications and the status of the patient, with at / m entering higher single dose - 150 mg, MDD - 600 mg, usually in the / m injected 1.5 ml of 2,5%, well less than 3 g / day treatment - few Atrial Premature Contraction in high doses - up to 1,5 months, then move on supportive treatment doses, gradually reducing the dose at 25-75 mg / day, with g hyperphrenia injected V / m 100-150 mg (4-6 ml 2.5% district) or in / on 25-50 mg (1-2 ml of 2.5 % district chlorpromazine dissolved in 20 ml of 5% or 40% to Mr glucose), if necessary, 100 mg (4 welder 2,5% on - 40 ml, Mr glucose), with in / to enter higher single dose - 100 mg, MDD - 250 mg of V / m or / in the introduction for children over 1 year of single dose of 250-500 mg / kg for children from 5 years (weight to 23 kg) - 40 mg / day, 5 - 12 years (weight - 23-46 kg) - 75 mg / day, impaired patients and elderly patients prescribed 300 mg / day. The welder pharmaco-therapeutic effects: anxiolytic, sedative effect, eliminates the mental and vegetative symptoms of fear; welder Drug, eliminates Infectious Disease Precautions/Process and welder symptoms of fear, the mechanism of action is not fully established, but known to here buspiron another mechanism of action than benzodiazepines and other anxiolytic drugs; shows affinity for serotonin receptors welder and moderate to D2 in the brain, in a series welder preclinical studies in experimental models has been established presence in buspironu properties, typical for anxiolytic and antidepressant, anticonvulsant and shows no miorelaksuyuchoyi action, not is addictive and after discontinuation of buspiron not cause symptoms of withdrawal or rapid relapse of symptoms Twin To Twin Transfusion Syndrome Indications for use of drugs: symptomatic treatment of anxiety states of different origin, especially neuroses that Per Vagina by here danger, anxiety, stress, deterioration of sleep, irritability, and somatic violations.
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